Q+A Hyaluronic Acid Facial Serum. A hydrating Hyaluronic Acid serum for healthy and plump skin. Works as a moisturiser for your face, Vegan Friendly, Fragrance Free, 30ml/1fl.oz

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Abdulkareem AA, Al Marah ZA, Abdulbaqi HR, Alshaeli AJ, Milward MR. A randomized double‐blind clinical trial to evaluate the efficacy of chlorhexidine, antioxidant, and hyaluronic acid mouthwashes in the management of biofilm‐induced gingivitis. International Journal of Dental Hygiene. 2020;18(3):268-277. doi:10.1111/idh.12432 Yang YJ, Lee WY, Kim YJ, Hong YP. A meta-analysis of the efficacy of hyaluronic acid eye drops for the treatment of dry eye syndrome. Int J Environ Res Public Health. 2021;18(5):2383. doi:10.3390/ijerph18052383 Singhal S, Hasan N, Nirmal K, et al. Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol. Trials. 2021;22(1). doi:10.1186/s13063-021-05053-7 Jun JH, Bang SP, Park HS, et al. A randomized multicenter clinical evaluation of sequential application of 0.3% and 0.15% hyaluronic acid for treatment of dry eye. Jpn J Ophthalmol. 2022;66(1):58-67. doi:10.1007/s10384-021-00885-x‌

Litwiniuk M, Krejner A, Speyrer MS, Gauto AR, Grzela T. Hyaluronic acid in inflammation and tissue regeneration. Wounds. 2016;28(3):78-88.‌ Cicek N, Yildiz N, Alpay H. Intravesical hyaluronic acid treatment in recurrent urinary tract infections in children with spina bifida and neurogenic bladder. Journal of Pediatric Urology. 2020;16(3):366.e1-366.e5. doi:10.1016/j.jpurol.2020.02.009 Oe M, Tashiro T, Yoshida H, et al. Oral hyaluronan relieves knee pain: a review. Nutrition Journal. 2015;15(1). doi:10.1186/s12937-016-0128-2 Ibraheem W, Jedaiba WH, Alnami AM, et al. Efficacy of hyaluronic acid gel and spray in healing of extraction wound: a randomized controlled study. Eur Rev Med Pharmacol Sci. 2022;26(10):3444-3449. doi:10.26355/eurrev_202205_28838 Essendoubi M, Gobinet C, Reynaud R, Angiboust JF, Manfait M, Piot O. Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy. Skin Research and Technology. 2015;22(1):55-62. doi:10.1111/srt.12228Urinary tract infections: A study conducted in 10 children aged 2 to 18 years with spina bifida and neurogenic bladder who performed clean intermittent catheterization (a technique for bladder drainage) showed that the instillation of 40 milligrams (mg) HA into the bladder weekly for four weeks then monthly for the following three months reduced symptomatic recurrent urinary tract infections. However, further multicenter randomized, controlled clinical trials with larger sample sizes and longer follow-ups are needed to confirm such promising results. Allergy to avian or avian-derived products: HA may be derived from rooster combs. Caution is advised if you have an allergy to eggs, feathers, or poultry. In addition to obtaining HA from animals, HA can also be obtained from bacteria. Aqua (Water), Propylene Glycol, Betaine, Sodium Hyaluronate, Bioasaccharide Gum-1, Caprylyl Glycol, Lactic Acid, Sodium Gluconate, Glycerin, Phenoxyethanol, Sodium Levulinate, Glyceryl Caprylate, Sodium Anisate, Xanthan Gum. Hyaluronic Acid Crosspolymer helps draw moisture into the skin and holds it safely in the upper layers of the skin to keep you looking fresh and hydrated. Polyglutamic Acid pairs perfectly with Hyaluronic Acid and helps draw even more moisture into the skin by forming a protective barrier that reduces moisture loss throughout the day - they are the ultimate pairing for dry and dehydrated skin. In addition, a unique Rice Bran extract delivers plenty of antioxidants and soothing Vitamin E for protection against environmental stressors and keeping your complexion feeling super soft.

Skin wrinkles: The typical HA dose for use in the setting of skin wrinkles is 120 milligrams (mg) HA capsule by mouth daily for 12 weeks. Although intradermal (within the skin) injection of HA has been studied in the field of esthetic dermatology, the effect of HA alone in serum-containing HA is unclear given that most products combine HA with other active ingredients (e.g., vitamins C and E) known to enhance skin health. Cancer: Hyaluronic acid has been shown to facilitate metastasis in colorectal cancer in laboratory models. However, it is unclear how this may translate into “real-life” settings. If you have a history of cancer, do not use hyaluronic acid supplements without consulting your healthcare provider. Jensen GS, Attridge VL, Lenninger MR, Benson KF. Oral intake of a liquid high-molecular-weight hyaluronan associated with relief of chronic pain and reduced use of pain medication: results of a randomized, placebo-controlled double-blind pilot study. Journal of Medicinal Food. 2015;18(1):95-101. doi:10.1089/jmf.2013.0174 Yang Z, Li M, Xiao L, Yi Z, Zhao M, Ma S. Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis. Brazilian Journal of Medical and Biological Research. 2020;53(8):e9886. doi:10.1590/1414-431X20209886 Gingivitis (gum disease): A double-blind parallel three-arm (0.12% chlorhexidine, 0.025% HA, and a water-based antioxidant mouthwash containing beta-carotene and vitamin E and C as active ingredients) clinical trial was conducted in 75 people 18 to 23 years with biofilm-induced gingivitis. It showed that all three interventions significantly reduced the plaque index (PI) after seven days compared to the baseline data. However, chlorhexidine showed a larger PI reduction than the HA and antioxidant mouthwashes.

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Kim JS, Lee SS, Kim TJ, Park YW. Serum hyaluronic acid levels do not explain morning stiffness in patients with fibromyalgia. Clinical Rheumatology. 2010;29(5):535-539. doi:10.1007/s10067-010-1372-z Gocmen G, Aktop S, Tüzüner B, Goker B, Yarat A. Effects of hyaluronic acid on bleeding following third molar extraction. J Appl Oral Sci. 2017;25(2):211-216. doi:10.1590/1678-77572015-0187 Q+A Hyaluronic Acid Daily Moisturiser refreshes your complexion with the best hydrating ingredients! Whilst the word 'acid' might seem scary, we produce Hyaluronic Acid naturally in our own bodies, as it helps to keep our skin hydrated!

Mikosinski J, Di Landro A, Kasztalska-Kazmierczak K, et al. Efficacy and safety of a hyaluronic acid-containing cream in the treatment of chronic, venous, or mixed-origin leg ulcers: a prospective, multicenter randomized controlled trial. Wounds. 2021;33(11):285-289.Colletti A, Cicero AFG. Nutraceutical approach to chronic osteoarthritis: from molecular research to clinical evidence. International Journal of Molecular Sciences. 2021;22(23):12920. doi:10.3390/ijms222312920 Gupta RC, Lall R, Srivastava A, Sinha A. Hyaluronic acid: molecular mechanisms and therapeutic trajectory. Frontiers in Veterinary Science. 2019;6. doi:10.3389/fvets.2019.00192 Monfort J, Rotés-Sala D, Segalés N, et al. Comparative efficacy of intra-articular hyaluronic acid and corticoid injections in osteoarthritis of the first carpometacarpal joint: results of a 6-month single-masked randomized study. Joint Bone Spine. 2015;82(2):116-121. doi:10.1016/j.jbspin.2014.08.008 Fibromyalgia: Blood levels of HA were measured in 69 Korean people designated female at birth with fibromyalgia, and it was found that the levels did not differ from those in the control group. Thus, the study indicated that HA levels did not correlate with disease severity.

Yang JJ, Zhang XM. Clinical efficacy of glucosamine plus sodium hyaluronate for osteoporosis complicated by knee osteoarthritis and Its influence on joint function and bone metabolic markers. Computational and Mathematical Methods in Medicine. 2022;2022:1-6. doi:10.1155/2022/6078254 Osteoarthritis: In a randomized study comparing the effect of intra-articular (within the joint) HA injection to betamethasone injection, people with osteoarthritis of the thumb underwent one cycle of three injections (one per week) of 0.5 cubic centimeters (cm 3) of HA 5 milligrams (mg). Intra-articular HA injection requires a prescription and is given as a shot to your knee joint by a trained healthcare professional. Ingredients: Aqua (Water), Propylene Glycol, Betaine, Sodium Hyaluronate, Biosaccharide Gum-1, Caprylyl Glycol, Lactic Acid, Sodium Gluconate, Glycerin, Phenoxyethanol, Sodium Levulinate, Glyceryl Caprylate, Sodium Anisate, Xanthan Gum Lugo JP, Saiyed ZM, Lane NE. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutrition Journal. 2015;15(1). doi:10.1186/s12937-016-0130-8 Simental-Mendía M, Sánchez-García A, Vilchez-Cavazos F, Acosta-Olivo CA, Peña-Martínez VM, Simental-Mendía LE. Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials. Rheumatology International. 2018;38(8):1413-1428. doi:10.1007/s00296-018-4077-2

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Oe M, Sakai S, Yoshida H, et al. Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period. Clinical, Cosmetic and Investigational Dermatology. 2017;10:267-273. doi:10.2147/CCID.S141845 Peanpadungrat P. Efficacy and safety of fish oil in treatment of knee osteoarthritis. J Med Assoc Thai. 2015;98( Suppl 3):S110-S114. Q+A Hyaluronic Acid Facial Serum works perfectly with Q+A Collagen Face Cream and Q+A Caffeine Eye Serum, giving you an ideal regime for dry or mature skin. Ingredients Unfer V, Tilotta M, Kaya C, et al. Absorption, distribution, metabolism and excretion of hyaluronic acid during pregnancy: a matter of molecular weight. Expert Opinion on Drug Metabolism & Toxicology. 2021;17(7):823-840. doi:10.1080/17425255.2021.1931682